Stuart Feinstein

Research Overview

Dr. Feinstein's investigations focus upon the normal and pathological action of the microtubule (MT) associated protein, tau. Normally, tau controls MT growing and shortening, thereby regulating the many essential functions performed by MTs such as axonal transport. Alternatively, tau dysfunction has long been associated with Alzheimer's and related dementias. Genetic analyses have demonstrated that mutations affecting either tau structure or regulation of its action can cause neuronal cell death and dementia.