A major goal of CALS-affiliated researchers is to reveal the fundamental biological basis of aging by understanding the molecules that regulate age progression and how aging mechanisms operate in cells. Our investigators perform studies on readily cultivated model animals and cells grown in the laboratory to illuminate the changes that occur as aging proceeds, how lifespan and aging programs can be experimentally modified, and how resilience against age-promoted degeneration can be promoted. Researchers are also investigating approaches to creating tissues and organs that can be used in regenerative medicine. Discoveries from this research can lead to improved methods for slowing, and even reversing, the aging process in humans.