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Aging and longevity are to a large extent determined by our genetic make-up. Indeed, it has become possible to extend healthspan and lifespan in many animals by manipulating their genomes. The genetic basis for lifespan is the result of evolutionary processes that have shaped the aging program, causing it to proceed at dramatically different rates between animal species. CALS research seeks to understand the genes and gene relationships that underlie the rate of aging in both model animals and through analysis of the genomes of human populations with differences in lifespan and occurrence of age-related diseases. They are also uncovering the genetic changes that occur in each of us as we age. Discoveries from these studies can lead to pharmacological interventions that slow aging rates and extend healthspan and lifespan.

 

Affiliated Researchers

Associate Professor, Anthropology
Comparative biology of cancer, human cancer in evolutionary perspective
Assistant Professor
Chemical Engineering
Biological Engineering
Epigenetic mechanisms of aging
Professor, Molecular, Cellular, and Development Biology
Alzheimer's and age-related neurodegenerative disease
Senior Scientist and Director of Scientific Communication, CALS
Aging and longevity research; analysis and communication of rigorous evidence-based intervention in aging and lifespan extension.
Distinguished Professor
Harriman Professor of Neuroscience
Molecular, Cellular, and Developmental Biology
Alzheimer's and age-related neurodegenerative disease
Duggan Professor and Distinguished Professor
Molecular, Cellular, and Developmental Biology
Impact of aging on the senses and animal behavior
Duggan Professor and Distinguished Professor
Molecular, Cellular, & Developmental Biology
Revitalizing dying cells
Assistant Professor, Molecular, Cellular, & Developmental Biology
DNA repair in aging
Director and Founder, CALS
Distinguished Professor
Wilcox Family Chair in Biotechnology
Director, Biomolecular Science and Engineering
Mechanisms of aging, longevity, and resilience
Assistant Professor, Molecular, Cellular, & Developmental Biology
Systems level mechanisms of cellular dysfunction caused by age-related decline and mechanisms for reversal
Professor, Ecology, Evolution and Marine Biology
Cellular and epigenetic mechanisms of aging, evolution and age-related diseases