Thomas Weimbs

Research Overview

The metabolic state of ketosis has evolved to allow humans (and other animals) to use their stored fat reserves for energy in times of food scarcity. In ketosis, blood glucose and insulin levels decrease, and the liver produces “ketones” to provide an alternative fuel source for cells. The main ketone, beta-hydroxybutyrate (BHB), is not only used for energy but is also a potent signaling molecule that affects numerous cellular pathways. Recent research suggests that the state of ketosis has unexpected health benefits and promotes healthspan and lifespan. Dr. Weimbs's research has focused on the role of ketosis in kidney health, chronic kidney disease, and the genetic disorder polycystic kidney disease. Chronic kidney disease is primarily caused by poor metabolic health culminating in type-II diabetes. Over 10% of the population (US and worldwide) are affected by chronic kidney disease. This has become a major health crisis. Dr. Weimbs and his team are investigating molecular pathways that mediate the observed beneficial effects of ketogenic metabolic therapy. Dr. Weimbs and his team are also devising strategies for implementing ketogenic metabolic therapies in clinical practice and have launched a startup company out of UCSB (Santa Barbara Nutrients) to translate research findings and make innovative products available to improve human health.